A DHL cargo plane crashed into a residential building near the airport while attempting to land in the Lithuanian capital.
According to the international news agency, the cargo plane was flying from the German city of Leipzig to the Lithuanian capital of Vilnius.
The cargo plane was scheduled to land at Vilnius Airport in Lithuania, where it was experiencing freezing temperatures.
The Boeing 737 of DHL, a leading global freight forwarding company, caught fire after hitting the building.
Firefighters extinguished the fire on the plane. Two people were taken to hospital with serious injuries from the scene.
One of the injured died while undergoing treatment at the hospital, while the condition of the other injured is said to be critical.
It is not yet clear whether the dead and injured were the crew of the plane or the unfortunate residents of the destroyed house.
The cause of the plane crash has not yet been determined. Initially, bad weather seems to be a factor.
Experts consider the Boeing 737, which is 31 years old, to be an old airframe, but it is not uncommon for it to be used for cargo flights.
Attempts by a foreign news agency to contact the airline company could not be answered.